In 1870, after a brutal run-in with an outlaw in a brothel, Mike Blueberry becomes marshal in Arizona where he keeps the peace between Whites and Apaches but an influx of Indian gold treasure-hunters threatens to lead to violence.
In 1870s America, the fury of a notorious gang leader is unleashed when a peaceful American settler avenges the death of his family. Then as his cowardly fellow townspeople betray him, he is forced to hunt down the outlaws alone.
In Bolivia, Butch Cassidy (now calling himself James Blackthorn) pines for one last sight of home, an adventure that aligns him with a young robber and makes the duo a target for gangs and lawmen alike.
Honest and hard-working Texas rancher Homer Bannon has a conflict with his unscrupulous, selfish, arrogant and egotistical son Hud, who sank into alcoholism after accidentally killing his brother in a car crash.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Hara. Together with an old Indian fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
A skilled cook has traveled west and joined a group of fur trappers in Oregon, though he only finds true connection with a Chinese immigrant also seeking his fortune. Soon the two collaborate on a successful business.